the efficacy of albendazole mebendazole combination against echinococcus granulosus protoscoleces (an in vitro evaluation)

The Efficacy of Albendazole Mebendazole Combination Against Echinococcus granulosus Protoscoleces (an in vitro evaluation)

A Comparison between the Effects of Albendazole and Mebendazole on the Enzymatic Activity of Excretory / Secretory Products of Echinococcus granulosus Protoscoleces in Vitro

BACKGROUND Hydatid cysts are formed in human body can be treated clinically by surgery or drugs such as albendazole (ABZ) and mebendazole (MBZ). The purpose of this study was comparing the effects of ABZ and MBZ on glutathione-S-transferase, alkaline phosphatase and protease enzymes activities in protoscoleces of hydatid cyst. METHODS The culture supernatants containing the parasite Excretory...

Efficacy of mebendazole and albendazole against Trichinella spiralis in mice.

Changes in the sensitivity of Trichinella spiralis to anthelmintic treatment during the first 3 days of infection in mice were studied. Oral administration of either mebendazole or albendazole at 6.25 mh/kg 2 hr after exposure to infection eliminated 95-100% of the worms as determined at necropsy on day 7 postinoculation. Beyond the first day of infection the sensitivity of the parasite to benz...

Strain characterization of Echinococcus granulosus protoscoleces of cattle origin using the in vitro vesicular development.

The aim of this work was to characterize the strain of protoscoleces of E. granulosus of cattle origin using the in vitro vesicular development. The in vitro development of these samples was compared to samples of sheep origin determined previously by genetic analyses as common sheep strain (G1). There were similarities between sheep and cattle samples not only in the time of microcysts formati...

In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes.

OBJECTIVES Infection of humans and domestic ruminants with the larval stage (metacestode) of Echinococcus granulosus results in cystic echinococcosis (CE). The metacestode causes a space-occupying lesion in visceral organs, most commonly in the liver. Benzimidazole carbamate derivatives, such as mebendazole and albendazole, are currently used for chemotherapeutic treatment of CE. In human patie...

Combined Effect of Flubendazole and Praziquantel on Echinococcus granulosus Protoscoleces and Microcysts

Background and objectives: Benzimidazoles such as albendazole are being used in some conditions to treat the hydatid disease, the common parasitic infections of humans and livestock that caused by Echinococcus granulosus. However, treatment with these drugs is not always with complete success. In this study we evaluate the in vitro efficacy of flubendazole (FLBZ) plus praziquantel (PZQ) against...